Palytoxin Acts on Na+,K+-ATPase but not Nongastric H+,K+-ATPase
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چکیده
منابع مشابه
Regulation of NaK-ATPase Activity by Neurotransmitters
The hitherto unknown NT-regulated mechanism of NaK-ATPase localized in the nerve ending membranes is found. The mechanism certainly has a functional significance and must be involved in the regulation – modulation of chemical synaptic transmission. On the other hand , the availability of the discovered specific protein, regulators (SFa and SFi) of synaptic origin, makes it possible to consider ...
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متن کاملSurface Plasmon Resonance Biosensor Method for Palytoxin Detection Based on Na+,K+-ATPase Affinity
Palytoxin (PLTX), produced by dinoflagellates from the genus Ostreopsis was first discovered, isolated, and purified from zoanthids belonging to the genus Palythoa. The detection of this toxin in contaminated shellfish is essential for human health preservation. A broad range of studies indicate that mammalian Na+,K+-ATPase is a high affinity cellular receptor for PLTX. The toxin converts the p...
متن کاملPalytoxin-induced Effects on Partial Reactions of the Na,K-ATPase
The interaction of palytoxin with the Na,K-ATPase was studied by the electrochromic styryl dye RH421, which monitors the amount of ions in the membrane domain of the pump. The toxin affected the pump function in the state P-E2, independently of the type of phosphorylation (ATP or inorganic phosphate). The palytoxin-induced modification of the protein consisted of two steps: toxin binding and a ...
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ژورنال
عنوان ژورنال: Journal of Membrane Biology
سال: 2007
ISSN: 0022-2631,1432-1424
DOI: 10.1007/s00232-007-9040-1